學(xué)習(xí)經(jīng)歷：
2010-2012??丹麥哥本哈根大學(xué)，博士
2005-2008??汕頭大學(xué)多學(xué)科研究中心，碩士
2001-2005??汕頭大學(xué)理學(xué)院，學(xué)士
工作經(jīng)歷：
2016.10-至今?? ???中國科學(xué)院廣州生物醫(yī)藥與健康研究院，PI
2013.01-2016.09? ?丹麥哥本哈根大學(xué)，博士后
致力于納米轉(zhuǎn)化醫(yī)學(xué)研究，主要研究方向：
1、核酸藥物（疫苗）開發(fā)及其納米靶向遞送系統(tǒng)研究；
2、生物材料合成及其微納結(jié)構(gòu)調(diào)控干細(xì)胞命運(yùn)器官再造。1、中國科學(xué)院戰(zhàn)略先導(dǎo)專項(xiàng)（mRNA關(guān)鍵成藥技術(shù)領(lǐng)域）， 2025-2028，專項(xiàng)負(fù)責(zé)人（首席專家）
2、國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目， 2024-2027，課題負(fù)責(zé)人
3、國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目， 2024-2028，骨干
4、廣州市重點(diǎn)研發(fā)計(jì)劃， 2023-2025，項(xiàng)目負(fù)責(zé)人
5、國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目， 2019-2023，課題負(fù)責(zé)人
6、國家科技重大專項(xiàng)， 2018-2020，子任務(wù)負(fù)責(zé)人
7、廣東省科技計(jì)劃項(xiàng)目， 2020-2021，項(xiàng)目負(fù)責(zé)人
8、廣州開發(fā)區(qū)國際科技合作項(xiàng)目， 2019-2020，子任務(wù)負(fù)責(zé)人
9、廣州市對外科技合作專題，2016-2018，項(xiàng)目負(fù)責(zé)人
1、2017年：高層次人才；
2、2013年：中國自費(fèi)優(yōu)秀留學(xué)生國家級(jí)獎(jiǎng)項(xiàng)。在高水平雜志發(fā)表80余篇論文，影響因子累計(jì)超600，引用5000余次，申請/授權(quán)發(fā)明專利20余項(xiàng)，主編撰寫英文論著一部。
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代表性論文（(#Join first co-author）
1.?Du K#, He G#, Huang F, Zhang X, Zhang X, Jie J, Huang C, Wu Y, Fan H, Lin Z*, Wu LP*. (2025) Macrophage-targeted lipid nanoparticles based on Dendron-like lipids deliver mTOR inhibitor to alleviate systemic lupus erythematosus. Chemical Engineering Journal, 519:165057
2.?Zhang D#, Chen J#, Lin H, Zhou M, Hou J, Sun W, Xing Q, Huang W, Zhang Y, Guo Y, Liu C, Lin A, Zhang C, Huang Y, Tao L-E, Xie B, Zhang J, Chen Q, Shan Y, Zhu Y, Pan G*, Wu LP*. (2025) A cocktail hydrogel promoting the functional interneurons regeneration of human neural progenitor cells for brain injury therapy. Journal of Advanced Research, https://doi.org/10.1016/j.jare.2025.05.063.
3.?Hou J#, Jie J#, Zhang D#, Chen J, Fang H, Sun D, Zhou M, Sun J*, Wu LP*. (2025) Aerogel library with varying porous structures and mechanics regulates motor neuron progenitor differentiation for spinal cord injury repair. Materials Today Bio, 35,102404
4.?Chen J#, Wu Y#, Huang J, Jie J, Huang C, Zhang D, Huang Y, Mao R, Zhao M*, Wu LP*. (2025) Microscopically Adaptable Bioink Guide Cell Compartmentalization toward Morphogenesis of a Functional Vasculature-Like System. Advanced Healthcare Materials, e02347
5.?Jie J, Ju J, Wang Z, Chen J*, Wu LP*, Sun J*. (2025) Organoid-Like Neurovascular Spheroids Promote the Recovery of Hypoxic-Ischemic Skin Flaps Through the Activation of Autophagy. Advanced Healthcare Materials, 14(15):2405154
6.?Liu X#, Li Z#, Li X#, Wu W, Jiang H, Zheng Y, Zhou J, Ye X, Lu J, Wang W, Yu L, Li Y, Qu L, Wang J, Li F, Chen L*, Wu LP*, Feng L*. (2024) A single-dose circular RNA vaccine prevents Zika virus infection without enhancing dengue severity in mice. Nature Communications, 15(1):8932
7.?Yuan W#, Huang C#, Deng W, Lai J, Chen J , Jie J, Wu Y, You T* and Wu LP*. (2024) Hyaluronic acid Methacryloyl/Chitosan Methacryloyl/3-Methacrylamidophenylboronic acid multifunctional hydrogel loading Exosome for diabetic wound healing. International Journal of Biological Macromolecules, 280, 135562.
8.?Hou J#, Jie J#, Wei X#, Shen X, Zhao Q,?Chai X, Pang H, Shen Z, Wang J, Wu LP*and?Xu J*.(2024) A core-shell-type nanosystem promotes diabetic wound healing through Photothermal-responsive release of transforming growth factor β. Journal of Nanobiotechnology , 22:449.
9.?Lin L, Zhu S, Huang H, Wu LP*, Huang J*.(2023) Chemically modified small interfering RNA targeting Hedgehog signalling pathway for rheumatoid arthritis therapy. Molecular Therapy - Nucleic Acids, 31, 88-104.
10.?Li Y#, Yang T#, Cheng Y#, Hou J#, Liu Z, Zhao Y, Chen S, Qin Z, Wang C, Song W, Ge H, Li C, Liang L, Guo L, Sun H, Wu LP*, Zheng H*. (2023) Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex. Cell Proliferation, 56(5):e13422.
11.?Guo Y, Wu LP*, Qiu F-G*.(2022) Highly diastereo- and enantioselective formal [4 + 2] cyclization of nitroalkenes and unsaturated ketoesters under phase-transfer catalysis. Organic letters, 45, 8370–8374 .
12.?Wu LP, Ficker M, Christensen JB, Simberg，D Trohopoulos PN, Moghimi SM*.(2021). ?Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking. Nature Communications, 12, 4858.
13.?Deng W, Zhang Y, Wang W, Song A, Mukama O, Huang J, Han X, Deng S, Lin Z, Habimana JD, Huang R, Peng K, Ni B, Zhang S, Yan X, Li J, Wu LP*, Li Z*.(2021) Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle. Stem Cell Research & Therapy,12, 548
14.?Pannuzzo M#, Esposito S#, Wu LP#, Key J, Aryal S, Celia C, Marzio LD, Moghimi SM*, Decuzzi P*.(2020) ?Overcoming nanoparticle-mediated complement activation by surface PEG-pairing. Nano letters, 20: 4312-4321.
15.?Wu LP*, Ahmadvand D, Su JA, Hall A, Tan XL, Farhangrazi AZ, Moghimi SM*.(2019). ?Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide. Nature Communications, 10, 4635.
16.?Wu LP*, Wang DY, Li ZB. (2020). Grand challenges in nanomedicine. Materials Science and Engineering C, 106, 110302.
17.?Xu Z, Wang D, Cheng Y, Yang M, Wu LP*. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C, 92, 1006–1015.
18.?Wu LP, Ficker M, Mejls?e SL, Hall A, Paolucci V, Christensen JB, Trohopoulos PN, Moghimi SM*. (2017). Poly-(amidoamine) dendrimers with a precisely core positioned sulforhodamine B molecule for comparative biological tracing and profiling. Journal of Controlled Release, 246, 88-97.
19.?Wang D, Wu LP*. (2017). Nanomaterials for delivery of nucleic acid to the central nervous system (CNS). Materials Science and Engineering: C, 70, 1039–1046.
20.? Wu LP, Uldahl KB, Chen FF, Benasutti H, Logvinski D, Vu V,. Banda NK, Peng X, Simberg D, Moghimi SM*. (2017) .Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice. Molecular Immunology, 90:273-279.
21.?Wu LP*, Moghimi SM. (2016) A nanoengineered peptidic delivery system with specificity for human brain capillary endothelial cells. Nanomedicine: NBM, 12(2), 474-475.
22.?Han J#, Wu LP#, Hou J, Zhao D, Xiang H*. (2015). Biosynthesis, Characterization and Hemostasis Potential of Tailor-Made Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Produced by Haloferax mediterranei. Biomacromolecules，16 (2), 578–588
23.?Wu LP, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM*. (2015). Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate chemistry，26(7), 1198-1211.
24.?Wu LP, Wang DY, Parhamifar L, Hall A, Chen G-Q, Moghimi, SM*. (2014). Poly (3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. Advanced healthcare materials, 3(6), 817-824.
25.?Wu LP#, You ML#, Wang DY, Peng GF, Wang ZH, CHEN G-Q*. (2013). Fabrication of Carbon Nanotubes (CNTs)/ Poly(3-hydroxyburyrate-co-3-hydroxyhexanoate) (PHBHHx) Nanocomposite Films for Human Mesenchymal Stem Cells (hMSCs) Differentiation. Polymer Chemistry, 4, 4490-4498.
26.?Wu LP#, Tripathi L#, Chen JC, Chen G-Q*. (2012).Synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxy -hexanoate [PHB-b-PHHx] by a beta-oxidation weakened Pseudomonas putida KT2442. Microbial Cell Factories, 11:44.
27.?Wu LP, Wang XJ, Cheng ST, Xu KT*. (2010). Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone). Acta Biomaterialia, 6, 1079-1089.
28.?Wu LP, Cheng ST, Li ZB, Chen G-Q*, Xu KT*. (2008). Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-lactide)- block-(ε-caprolactone)] triblock copolymers. Polymer International, 57, 939-949.
29.?Kim HS, Chen JY, Wu LP, Wu JH, Xiang H*, Leong KW, Han J*. (2020) ?Prevention of excessive scar formation using nanofibrous meshes made of biodegradable elastomer poly(3-hydroxybutyrate- co-3-hydroxyvalerate). Journal of Tissue Engineering, 11, 1–12.
30.?Xu Z, Wang D, Cheng Y, Yang M, Wu LP*. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C, 92, 1006–1015.
31.? Chen C#, Wang G#, Griffin J, Brenneman B, Banda N, Holers V, Backos D, Wu LP, Moghimi SM, Simberg D*. (2017). Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo. Nature Nanotechnology, 12(4), 387-393.
32.?Wang D, Wu LP*. (2017). Nanomaterials for delivery of nucleic acid to the central nervous system (CNS). Materials Science and Engineering: C, 70, 1039–1046.
33.?Uldahl KB#, Wu LP#, Hall A, Papathanasiou P, Peng X*, Moghimi SM*. (2017). Recognition of extremophilic archaeal viruses by eukaryotic cells: a promising nanoplatform from the third domain of life. Scientific Reports, 6, 37966.
34.?Wu LP, Uldahl KB, Chen FF, Benasutti H, Logvinski D, Vu V,. Banda NK, Peng X, Simberg D, Moghimi SM*. (2017) .Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice. Molecular Immunology, 90:273-279.
35.?Han J#, Wu LP#, Hou J, Zhao D, Xiang H*. (2015). Biosynthesis, Characterization and Hemostasis Potential of Tailor-Made Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Produced by Haloferax mediterranei. Biomacromolecules，16 (2), 578–588.
36.? Wu LP, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM*. (2015). Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate chemistry，26(7), 1198-1211.
37.?Wu LP, Wang DY, Parhamifar L, Hall A, Chen G-Q, Moghimi, SM*. (2014). Poly (3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. Advanced healthcare materials, 3(6), 817-824.
38.?Wu LP#, You ML#, Wang DY, Peng GF, Wang ZH, CHEN G-Q*. (2013). Fabrication of Carbon Nanotubes (CNTs)/Poly(3-hydroxyburyrate-co-3-hydroxyhexanoate) (PHBHHx) Nanocomposite Films for Human Mesenchymal Stem Cells (hMSCs) Differentiation. Polymer Chemistry, 4, 4490-4498
39.?Tripathi L#, Wu LP#, Chen JC, Chen G-Q*. (2012).Synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxyhexanoate [PHB-b-PHHx] by a beta-oxidation weakened Pseudomonas putida KT2442. Microbial Cell Factories, 11:44.
40.? Wu LP, Wang XJ, Cheng ST, Xu KT*. (2010). Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone). Acta Biomaterialia, 6, 1079-1089
41.?Wu LP, Cheng ST, Li ZB, Chen G-Q*, Xu KT*. (2008). Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-lactide)- block-(ε-caprolactone)] triblock copolymers. Polymer International, 57, 939-949.
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代表性發(fā)明專利
1.??一種核酸遞送系統(tǒng)及其制備方法和應(yīng)用（授權(quán)）。專利號(hào)：ZL202110572364.7。
2.??一種抗疲勞雙親性有機(jī)水凝膠及其制備方法和應(yīng)用（授權(quán)）。專利號(hào)： ZL202110573865.7。
3.??一種雙網(wǎng)狀氣凝膠及其制備方法和應(yīng)用（授權(quán)）。專利號(hào)： ZL 202211687482.3。
4.??一種樹狀樣脂質(zhì)化合物、脂質(zhì)體、脂質(zhì)復(fù)合物、脂質(zhì)納米顆粒及其應(yīng)用。申請?zhí)枺?02210651251.0； PCT/CN2023/097308。
5.??一種可質(zhì)子化類脂化合物、脂質(zhì)體、脂質(zhì)納米顆粒及其應(yīng)用。申請?zhí)枺篊N202410643969.4。
6.??一種水凝膠及其制備方法和應(yīng)用。申請?zhí)枺篊N202410820906.1。
7.??一種編碼小鼠發(fā)育多能性相關(guān)蛋白3mSTELLA的mRNA及其應(yīng)用。申請?zhí)枺篊N202411403331.X。
8.??一種編碼伴侶蛋白頂端結(jié)構(gòu)域的mRNA及其應(yīng)用。申請?zhí)枺?02510306213.5。
9.??一種類器官樣神經(jīng)血管球體模型及其制備方法和應(yīng)用。申請?zhí)枺?025103756540。
10.?一種可電離脂質(zhì)化合物及其應(yīng)用。申請?zhí)枺?025105666318。
11.?一種可電離脂質(zhì)化合物及其應(yīng)用。申請?zhí)枺?025105666248。
12.?一種編碼阿達(dá)木單抗的RNA組合物及其應(yīng)用。申請?zhí)枺?025110571962。
13.?一種組織工程神經(jīng)導(dǎo)管及其制備方法和應(yīng)用。申請?zhí)枺?025106357557。
14.?Peptidic nanodelivery composition targeting two receptors. PCT：PCT/EP2014/067651。
15.?Nano-systems for therapy and/or diagnosis and/or therapy monitoring and/or theranostics of disease. PCT：PCT/EP2017/060579。
