
2017年獲暨南大學(xué)博士學(xué)位,2017-2022年在中山大學(xué)從事博士后研究。目前,任廣州健康研究院副研究員,碩士研究生導(dǎo)師,中國科學(xué)院青年創(chuàng)新促進(jìn)會會員。主要從事基于核酸納米藥物的腫瘤免疫治療研究,累計(jì)已發(fā)表論文28篇,H指數(shù)19。其中,以第一(含共第一)或通訊作者發(fā)表SCI論文12篇,累計(jì)被引1200余次。中國科學(xué)院B類先導(dǎo)專項(xiàng)(國家科技重大任務(wù))課題負(fù)責(zé)人,國家重點(diǎn)研發(fā)計(jì)劃子任務(wù)負(fù)責(zé)人,主持國家自然科學(xué)基金青年基金、廣東省自然科學(xué)基金、中國博士后科學(xué)基金、廣州市科技計(jì)劃項(xiàng)目。獲授權(quán)發(fā)明專利2項(xiàng)。受邀擔(dān)任《Cancer Drug Resistance》雜志青年編委、中國藥理學(xué)會學(xué)術(shù)會員、廣東省研究型醫(yī)院學(xué)會會員。
基于核酸納米藥物的腫瘤免疫治療研究
1.?中國科學(xué)院戰(zhàn)略先導(dǎo)專項(xiàng),2025-2028,課題負(fù)責(zé)人
2.?國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目,2024-2028,子任務(wù)負(fù)責(zé)人
3.?中國科學(xué)院青年創(chuàng)新促進(jìn)會項(xiàng)目,2025-2028,項(xiàng)目負(fù)責(zé)人
4.?廣州市科技計(jì)劃項(xiàng)目,2024-2025,項(xiàng)目負(fù)責(zé)人
5.?國家自然科學(xué)基金青年項(xiàng)目,2020-2022,項(xiàng)目負(fù)責(zé)人
6.?廣東省自然科學(xué)基金面上項(xiàng)目,2018-2022,項(xiàng)目負(fù)責(zé)人
7.?中國博士后科學(xué)基金面上項(xiàng)目,2018-2021,項(xiàng)目負(fù)責(zé)人
代表性論文(#Join first co-author,*corresponding author):
[1]?Li Y#, Bai L#, Yu H, Cai D, Wang X, Huang B, Peng S, Huang M, Cao G, Kaz AM, Grady WM, Wang J, and Luo Y*. Epigenetic inactivation of α-internexin accelerates microtubule polymerization in colorectal cancer. Cancer Res. 2020; 80(23):5203-15.
[2]?Zhu M#, Bai L#, Liu X#, Peng S, Xie Y, Bai H, Yu H, Wang X, Lin J, Wu L, Huang M, Li Y*, Luo Y*. Silence of dependence receptor CSF1R activates tumor-associated macrophages in colorectal cancer. J ImmunoTher Cancer. 2022; 10:e005610.
[3]?Li Y#, Lei Y#, Yao N, Wang C, Hu N, Ye W, Zhang D* and Chen Z*. Autophagy and multidrug resistance in cancer. Cancer Commun. 2017; 36(1): 52.
[4]?Fang C #, Liu Z #, Bai L #, Ma L, Xiong W, Sun L, Wu L, Ni J, Zhang W, Zhu Y, Luo Y *, Li Y*, Zhang C*. A new sodium ionophore Polydecalinmycin with octalin ring improves skin wound healing in diabetes. Nature Communications. (Under review, NCOMMS-25-70185)
[5]?Bai L#, Wu L#, Zhang C, Liu Z, Ma L, Ni J, He D, Zhu M, Peng S, Liu X, Yu H, Lei Y, Luo Y, Zhang Y, Wang X*, Wei G*, Li Y*. Replenishment of mitochondrial Na+ and H+ by ionophores potentiates cutaneous wound healing in diabetes. Materials Today Bio. 2024; 26 (2024) 101056.
[6]?Yao N#, Li Y#, Lei Y#, Hu N, Chen W, Yao Z, Yu M, Liu J, Ye W* and Zhang D*. A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2016; 35(1): 192.
[7]?Peng S#, Li Y#, Huang M, Tang G, Xie Y, Chen D, Hu Y, Yu T, Cai J, Yuan Z, Wang H, Wang H, Luo Y*, Liu X*. Metabolomics reveals that CAF-derived lipids promote colorectal cancer peritoneal metastasis by enhancing membrane fluidity. Int J Biol Sci. 2022; 18(5):1912-1932
[8]?Lei Y#, Zhang E#, Bai L*, Li Y*. Autophagy in cancer immunotherapy. Cells. 2022. 11 (19) :2996
[9]?Liu D#, Li Y#, Yang D, Wang C, Xu J, Yao N, Zhang X, Chen Z, Ye W* and Zhang DM*. Ganoderma lucidum derived ganoderenic acid B reverses ABCB1-mediated multidrug resistance in HepG2/ADM cells. Int J Oncol. 2015; 46(5): 2029-38.
[10]?Liu D#, Li Y#,?Yao N,Xu J, Chen Z, Yiu A, Zhang C, Ye W*, Zhang D*. Acerinol, a cyclolanstane triterpenoid from Cimicifuga acerina, reverses ABCB1-mediated multidrug resistance in HepG2/ADM and MCF-7/ADR cells. Eur J Pharmacol. 2014; 733C: 34-44.
代表性專利:
1.?一類化合物促皮膚損傷修復(fù)的用途. 中國發(fā)明專利. ZL202010566166.5, 第一發(fā)明人
2.?化合物促皮膚損傷修復(fù)的用途. 中國發(fā)明專利. ZL202111044412.1, 第一發(fā)明人

